A priori, the Israeli RNA-based vaccination has several potential risks. Vaccination works as a prophylactic. Vaccination of individuals while they are exposed to a pandemic has several adverse consequences. 1. Vaccination processes usually imply temporary immune system weakening, before vaccine-induced immunity is acquired. Hence, the vaccinated are fragilized during the vaccination process, and more likely…
Tag: Autoimmunity
Mercola reports “COVID Vaccines May Bring Avalanche of Neurological Disease”
The typical unprecedented vaccine takes 12 years to develop, and of all the unprecedented vaccines in development, only 2% are projected to ever make it through all Phase 2 and 3 clinical phases of testing The COVID-19 vaccine was developed with Operation Warp Speed in less than one year, which makes it virtually impossible to…
Hooman Noorchashm reports “A Letter To Robert F. Kennedy Jr. And Friends: On COVID-19 Vaccine Efficacy, Safety, and the Potential Danger Of Indiscriminate Vaccination In The Already Infected”
The COVID-19 vaccine was tested too rapidly and the clinical trials, which demonstrated its extreme efficacy in creating immunity, did not have sufficient granularity to assess its safety in certain subsets of the population. Again, as a cellular immunologist, my thinking about the safety of this vaccine does not operate in generalities. Rather, I ask: what…
Frontiers in Immunology reports “Reaction of Human Monoclonal Antibodies to SARS-CoV-2 Proteins With Tissue Antigens: Implications for Autoimmune Diseases”
We sought to determine whether immune reactivity occurs between anti-SARS-CoV-2 protein antibodies and human tissue antigens, and whether molecular mimicry between COVID-19 viral proteins and human tissues could be the cause. We applied both human monoclonal anti-SARS-Cov-2 antibodies (spike protein, nucleoprotein) and rabbit polyclonal anti-SARS-Cov-2 antibodies (envelope protein, membrane protein) to 55 different tissue antigens….
JCI Insight reports “Anti–spike IgG causes severe acute lung injury by skewing macrophage responses during acute SARS-CoV infection”
Newly emerging viruses, such as severe acute respiratory syndrome coronavirus (SARS-CoV), Middle Eastern respiratory syndrome CoVs (MERS-CoV), and H7N9, cause fatal acute lung injury (ALI) by driving hypercytokinemia and aggressive inflammation through mechanisms that remain elusive. In SARS-CoV/macaque models, we determined that anti–spike IgG (S-IgG), in productively infected lungs, causes severe ALI by skewing inflammation-resolving…
Newsmax reports “HPV Vaccine Linked to Autoimmune Events”
The Gardasil vaccine was first approved for the prevention of the human papillomavirus (HPV) in June 2006. It was eventually added to the childhood immunization schedule and recommended to all girls between the ages of 11 and 12. But since then, there have been reports linking Gardasil to autoimmune illnesses. In order to see if…
Cell Research reports “Increased IL-1β activation, the culprit not only for defective insulin secretion but also for insulin resistance?”
Regardless of the precise underlying mechanism, an impressive number of genetic animal models now demonstrate a role for the inflammasome in mediating IL-1β-induced insulin resistance. This is further supported by earlier intervention studies showing that IL-1 blockade in animal models of diabetes improved both insulin secretion and sensitivity. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3193499/
Journal of Translational Autoimmunity reports “Pathogenic priming likely contributes to serious and critical illness and mortality in COVID-19 via autoimmunity”
Homology between human and viral proteins is an established factor in viral- or vaccine-induced autoimmunity. Failure of SARS and MERS vaccines in animal trials involved pathogenesis consistent with an immunological priming that could involve autoimmunity in lung tissues due to previous exposure to the SARS and MERS spike protein. Exposure pathogenesis to SARS-CoV-2 in COVID-19…
Elsevier reports “Gulf war illness, post-HPV vaccination syndrome, and Macrophagic Myofasciitis possibly linked to vaccine-induced autoimmune dysautonomia”
Post-HPV vaccination syndrome, Macrophagic Myofasciitis, and gulf war illness analogy suggests that some vaccines or multiple vaccinations in a very short period of time may induce, in susceptible individuals, chronic pain, fatigue and dyscognition. Vaccine-induced autoimmune dysautonomia is hypothesized as the common pathogenetic mechanism for this symptom cluster. https://www.sciencedirect.com/science/article/abs/pii/S1568997220301671