Despite side effects from the first dose, he followed through with the second dose. Clapton was previously diagnosed with peripheral neuropathy, which causes nerve damage in the arms and legs that can result in pain, burning, numbness, and the feeling of pins-and-needles. Following his second dose, Clapton lost the use of his hands almost completely.
Clapton also said the vaccine caused damage to his immune system, as his peripheral neuropathy got significantly worse. Clapton has worried about speaking out for fear of losing friends and family and believes this and fear of reprisal has prevented many from speaking out.